Jelena Vasiljevic¹, Natasa Zivic², Jelena Pribic³, Ksenija Kanjer³, Wojtek Jonakowski¹, Jelena Sopta⁴, Dragica Nikolic-Vukosavljevic³ and Marko Radulovic³, ¹Institute Mihajlo Pupin, Serbia, ²University of Siegen, Germany, ³Institute of Oncology and Radiology of Serbia, Serbia and ⁴University of Belgrade, Serbia

Based on pressing need for predictive performance improvement, we explored the value of pretherapy tumour histology image analysis to predict chemotherapy response. It was shown that multifractal analysis of breast tumour tissue prior to chemotherapy indeed has the capacity to distinguish between histological images of the different chemotherapy responder groups with accuracies of 91.4% for pPR, 82.9% for pCR and 82.1% for PD/SD.

breast cancer; prediction; histology; chemotherapy, fractal; multifractal; drug response